Welcome to NRAMM
The National Resource for Automated Molecular Microscopy is a Biomedical Technology Research Centers supported by the NIH National Center for Research Resources.
One of the major goals for the current five year grant period is to expand our automated infrastructure in order to provide a complete and integrated pipeline for the reconstruction of macromolecular machines. This infrastructure is primarily aimed at supporting the overall NRAMM mission of developing cryoEM as a mainstream and efficient methodology on a par with, and complementary to, X-ray crystallography. An additional major goal of the core technological and research developments is to address some of the fundamental questions and issues that remain as barriers to deriving high resolution 3D maps of molecular machines using cryoEM. The technology that we are developing provides us with a unique opportunity to systematically probe some of the current limitations of the method.
Recent Featured Image:
A preliminary image of double layered rotavirus particles taken on the direct detection device.
See Featured Images pages for more. |
Recent News:
Identifying and observing the molecules that form ribosomes—the cellular factories that build the proteins essential for life—has for decades been a key goal for biologists. A new study performed at NRAMM, which appears in the October 29, 2010 issue of the journal Science, yielded pictures of the chemical intermediate steps in ribosome creation. Read more… |
AMI Forums:“Investigation of Circulating Endothelial Cells as Potential Predictive Biomarkers in Acute Coronary Syndromes“ Samir Damani, M.D., Pharm. D. - Cardiologist, Scripps Clinic Friday October 28, 2011 @ 12:00 p.m. CIMBio 1st Floor Conference Room
Samir Damani, M.D., Pharm.D., and colleagues at the Scripps Translational Science Institute and Veridex have been collaborating to explore the use of circulating endothelial cells (CECs) as a predictive non-invasive biomarker in coronary artery disease (CAD). Coronary artery disease and its downstream complications remain the leading cause of death worldwide. While stable coronary artery disease (CAD) is readily diagnosed through functional stress testing and coronary angiography, acute cardiovascular events such as myocardial infarction remain highly unpredictable. Accordingly, there is a significant need for a non-invasive biomarker such as a protein, nucleic acid, or cellular based assay that can identify those individuals who are at the greatest risk for sudden arterial disruptive events before they are clinically manifested. Our data demonstrate that circulating endothelial cells hold promise to fill this void. |
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